Base de dados : HANSEN Pesquisa : HANSENIASE VIRCHOWIANA/IMUNOL [Descritor de assunto] Referências encontradas : 62 [refinar] Mostrando: 1 .. 20   no formato [Detalhado]

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Id: 27299 Autor: Klatser, Paul R; Janson, Anneke M; Thole, Jelle E. R; Buhrer, Samira; Bos, Corinne; Soebono, Hardyanto; Vries, Rene R. P. de. Título: Humoral and cellular immune reactivity to recombinant M. leprae antigens in HLA-Typed leprosy patients and healthy controls. Fonte: Int. J. Lepr;65(2):178-189, Jun. 1997. tab, graf. Resumo: In our search for Mycobacterium leprae antigens that might specifically induce immunity or immunopathology, we have tested both humoral and cellular immune reactivity against purified recombinant M. leprae antigens in 29 paucibacillary (PB), 26 multibacillary (MB) leprosy patients, and 47 matched healthy contacts. The following M. leprae antigens were tested: 2L-1 (65L-1, GroEl-1), 2L-2 (65L-2, GroEl-2), 4L (SoDA), 43L, 10L (B) and 25L (Sra). The individuals were also typed for HLAD-RB1 and DQB1 in order to see whether leprosy status and/or immune reactivity to these antigens might be associated with certain HLA types. We also tested sera from another 48 patients before, during and after multidrug therapy (MDT) to study the relationship between antibody reactivity to recombinant M. leprae antigens and MDT. Antibody titers to the four recombinant M. leprae antigens tested and to D-BSA were higher in MB patients compared to PB patients and healthy controls, and declined with treatment. From a diagnostic or monitoring point of view none of the recombinant antigens seemed to be an improvement over D-BSA, mainly due to the lower sensitivity. IgG subclasses were measured in positive sera of untreated patients. These were mainly of the IgG1 and IgG3 subclasses, but subclass diversity was also observed and antigen dependent: all four subclasses could be detected against 10L (B), only IgG1 and IgG3 against 43L and only IgG1 against 25L and 2L-1. Cellular immune reactivity against the purified recombinant M. leprae antigens was measured in a lymphocyte stimulation test (LST). As for M. leprae, there was an inverse correlation between antibody and T-cell reactivity. However, the number of LST responders to recombinant antigens was much lower than to M. leprae. The 43L antigen was recognized most often (19%-24% of individuals tested) and more often than the 10L (B) antigen (10%-12%). No clear correlation was observed with leprosy type or protection and, in general, M. leprae nonresponders were also negative with recombinant antigens. Finally, we confirmed that HLA-DRB1*02 is associated with leprosy in this population, and we observed an association between DQB1*0601 and lepromatous leprosy. The number of positive individuals was too small to allow a meaningful analysis of the relationship between HLA type and immune reactivity. Although these data do not allow a conclusion as to one of these purified recombinant antigens being either protection or disease related, the antigen-dependent IgG subclass diversity warrants further study on antigen-specific qualitative differences in immune reactivity that may be relevant for the outcome of an infection with M. leprae. (AU)^ien. Descritores: Hanseníase Dimorfa/sangue Hanseníase Dimorfa/imunol Hanseníase Virchowiana/sangue Hanseníase Virchowiana/imunol Hanseníase Tuberculóide/sangue Hanseníase Tuberculóide/imunol Localização: BR191.1

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Id: 27282 Autor: Alfaro-Bustamante, Fernando; Ramirez-Flores, Gabriela; Gonzales-Mendonza, Amado; Islas-Rodriguez, Alfonso; Fafutis-Morris, Mary. Título: Effect of phorbol myristate acetate (PMA) and ionophore A23187 on interleukin-2 levels and proliferation of activated T lymphocytes from patients with lepromatous leprosy. Fonte: Int. J. Lepr;65(1):73-79, Mar., 1997. tab, graf. Resumo: The immunodeficiency present in patients with lepromatous leprosy is characterized by the limited proliferation of T lymphocytes, and is explained in part by the impaired synthesis of interleukin-2 (IL-2). Diacylglycerol (DAG) and calcium produce the activation of PKC, ERK and JNK kinases, implying a normal IL-2 response. Phorbol esters, such as PMA, can substitute for DAG and are mitogenic to human T and B cells activating several cytokine-encoding genes. Ionophore A23187 increases calcium permeability across the cellular membrane to the cytosol of lymphoid cells and is considered a co-mitogen of T lymphocytes. Here we report that: 1) PHA-activated T lymphocytes from LL patients can be separated in vitro into two groups: a) responders (R) with a stimulation index (SI) of > 10 and (b) nonresponders (NR) with a SI of < 10. 2) The proliferative responses of cells from LL(R), LL(NR) and normal subjects were measured after being stimulated with: I, PHA, PMA, PMA + I PHA + PMA and PHA + PMA + ionophore (PPI). The most important result occurs in LL(NR) patients whose cells did not respond to PHA stimulation but increased to normal levels of proliferation when they were stimulated with PMA. Furthermore, the three groups, (NR, R and normals) strongly increased their responses when they were incubated with PPi. 3) Finally, Il-2 concentrations in the supernatants of cultures of T lymphocytes from LL(NR), LL(R) and controls were relatively low when they were incubated with PHA or PMA, but the addition of ionophore to PMA and the combination of PHA + PMA strongly increased the production of IL-2 in all of them, reaching the optimum IL-2 concentration when PPI is used. It can be concluded that the use of PMA, analogous to DAG, and ionophore A23187 (calcium increaser) in cultures of mitogen-activated T lymphocytes from LL patients induced the expression of the IL-2 gene, thus correcting the inadequate proliferation of T cells from LL patients. (AU)^ien. Descritores: Hanseníase Virchowiana/imunol Acetato de Tetradecanoilforbol/farmacol Localização: BR191.1

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Id: 27279 Autor: Barrera, Silvia de la; Finiasz, Marta; Fink, Susana; Valdez, Raul; Bottasso, Oscar; Balina, Luis Maria; Sasiain, Maria del Carmen. Título: Differential development of CD4 and CD8 cytotoxic T cells (CTL) in PBMC across the leprosy spectrum IL-6 with IFN-gamma or IL-2 generate CTL in multibacillary patients. Fonte: Int. J. Lepr;65(1):45-55, Mar., 1997. tab, graf. Resumo: In the present study we evaluated the contribution of CD4 and CD8 T cells on the antigen-specific cytotoxic activity induced by whole Mycobacterium leprae in leprosy patients and normal controls (N) as well as the modulation of this activity by some cytokines. Peripheral blood mononuclear cells (PBMC) from N or from leprosy patients were stimulated with antigen in the presence or absence of cytokines for 7 days. M. leprae-stimulated PBMC were depleted of CD4 or CD8 antigen-bearing cells and employed as effector cells in a 4-hr [31Cr]-release assay against autologous M. leprae-pulsed macrophages. Our results demonstrate that both CD4 and CD8 T cells contribute to M. leprae-induced cytotoxic activity, with differences observed in paucibacillary (PB) and multibacillary (MB) patients. CD8-mediated cytotoxic activity is higher than that of CD4 cells in PB patients, while in MB patients CD4 cytotoxicity is predominant. Our data also demonstrate that the generation of CD4 and CD8 cytotoxic T lymphocytes (CTL) can be modulated differentially by interleukin-4 (IL-4), IL-6, gamma interferon (IFN-gamma), or IL-2. Although MB patients developed the lowest CTL response, cytokines such as IL-6 plus IL-2 or IFN-gamma were able to generate both CD4 and CD8 cytotoxic T cells from MB patients. In PB patients, IL-6 plus IFN-gamma displayed the highest stimulation on CD8 effector cells. Thus, an important role may be assigned to IL-6, together with IL-2 or IFN-gamma, in the differentiation of M. leprae-specific CTL effector cells. (AU)^ien. Descritores: Linfócitos T CD4-Positivos/imunol Linfócitos T CD8-Positivos/imunol Hanseníase Dimorfa/imunol Hanseníase Virchowiana/imunol Hanseníase Tuberculóide/imunol Localização: BR191.1

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Id: 27233 Autor: Rea, Thomas H; Sieling, Peter A. Título: Delayed-type hypersensitivity reactions followed by erythema noodosum leprosum. Fonte: Int. J. Lepr;66(3):316-327, Sept. 1998. tab. Resumo: Reported herein are 13 borderline lepromatous (BL) or subpolar lepromatous (LLs) patients who presented with or developed delayed-type hypersensitivity (DTH) reactions after initiation of antibacterial therapy, but who subsequently developed erythema nodosum leprosum (ENL), the DTH to ENL group. During the same time, three LLs patients had ENL followed by relapse-associated DTH, a significant (p < 0.05) difference in sequence of the two conditions. The DTH to ENL group had statistically significant higher biopsy indexes at the time of diagnosis of the DTH reaction compared with two DTH control groups, 7 multibacillary patients presenting with DTH reactions and 15 BL or LLs who developed DTH reactions after starting treatment but had no ENL. DTH-associated histologic changes were less well developed in the DTH to ENL group than in either of the two control groups. In the DTH to ENL group, 77% required prednisone in addition to thalidomide to achieve a complete remission in contrast to only 10% of 21 ENL clinical controls. In the DTH to ENL group, the classical histologic ENL pattern was present in only 31% of these patients, in contrast to 88% of 33 ENL histologic controls. In 9 of 9 of the DTH to ENL patients studied, after the ENL remitted, Mycobacterium leprae-sonicate-stimulated lymphocyte transformation tests gave stimulation indexes within the range of our tuberculoid (TT) and borderline tuberculoid (BT) patients, in contrast to absent responses in 6 ordinary, longterm-treated patients who had had ENL. (AU)^ien. Descritores: Hanseníase Dimorfa/quimioter Hanseníase Dimorfa/imunol Hanseníase Virchowiana/quimioter Hanseníase Virchowiana/imunol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n3/v66n3a02.pdf - en. Localização: BR191.1

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Id: 27170 Autor: Rivero-Nava, Laura; Quesada-Pascual, Fausto; Estrada-Garcia, Iris; Estrada-Parra, Sergio; Santos-Argumedo, Leopoldo. Título: Cellular immune responses of health and Mycobacterium leprae-inoculated armadillos (Dasypus novemcinctus). Fonte: Int. J. Lepr;66(4):485-487, Dec. 1998. graf. Descritores: Tatus/genet Hanseníase Virchowiana/imunol Mycobacterium leprae/imunol Limites: Animais Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n4/v66n4cor02.pdf - en. Localização: BR191.1

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Id: 27168 Autor: Freire, Beatriz F. A; Ferraz, Alexandre A. F; Nakayama, Edson; Ura, Somei; Queluz, Thais T. Título: Anti-neutrophil cytoplasmic antibodies (ANCA) in the clinical forms of leprosy. Fonte: Int. J. Lepr;66(4):475-482, Dec. 1998. tab. Resumo: Anti-neutrophil cytoplasmic antibodies (ANCA) are autoantibodies against enzymes present in primary granules of neutrophils and lysosomes of monocytes detected in systemic vasculitis and in other diseases, including infections. ANCA are markers of active Wegener granulomatosis, which presents some anatomo-pathologic and immune response features similar to those of leprosy. Thus, we raised the hypothesis that ANCA may be present in leprosy as markers specifically linked to the presence of vasculitis. The aim of this study was to determine the presence of ANCA in leprosy and its correlation with the clinical forms of the disease. Sera from 60 normal individuals and from 59 patients with different clinical forms of leprosy were studied. The patients were also allocated into reactional and nonreactional groups. By indirect immunofluorescence, ANCA were positive, an atypical pattern (A-ANCA), in 28.8% of the patient sera. A-ANCA predominated, although not significantly (p > 0.05), in the reactional groups 37.9% vs 20.0%), and in those at the lepromatous pole (41.6% vs 20.0%). There was no correlation between ANCA positivity and either disease duration, disease activity, or therapeutic regimen (p > 0.05). An interesting finding was the correlation between ANCA and gender: 94.1% of ANCA-positive patients were males (p < 0.01), a feature that so far has not been reported in ANCA-related diseases and for which there is no explanation at the moment. By ELISA, the sera of the lepromatous leprosy patients did not show activity against either PR3, MPO, HLE, the most common ANCA antigens. Because A-ANCA are nonspecific, this finding requires further investigation for the determination of the responsible antigen(s). In conclusion, A-ANCA are present in 28.8% of leprosy patients but are not related to vasculitis in the erythema nodosum leprosum reaction and are not a marker of a specific clinical form. (AU)^ien. Descritores: Hanseníase Virchowiana/diag Hanseníase Virchowiana/imunol Granulócitos/imunol Limites: Humanos Masculino Feminino Criança Adolescente Adulto Idoso Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n4/v66n4a05.pdf - en. Localização: BR191.1

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Id: 27144 Autor: Sinha, Sudhir; Mcentegart, Anne; Girdhar, Bhawneshwar K; Bhatia, Amarjit S; Sengupta, Utpal. Título: Appraisal of two mycobacterium leprae specific serological assays for monitoring chemotherapy in lepromatous (LL/BL) leprosy patients. Fonte: Int J Lep;57(1):24-32, Mar. 1989. ^bgraf, ^btab. Resumo: Two of the Mycobacterium leprae-specific assays--a serum antibody competition (for an epitope on 35-kDa protein) test (SACT) and an enzyme-linked immunosorbent assay (ELISA) for the disaccharide epitope of phenolic glycolipid-I (PGDS)--were comparatively evaluated as tools for monitoring chemotherapy in 125 lepromatous leprosy (LL/BL) patients. An adaptation of the SACT from a radioimmunoassay (RIA) to an ELISA procedure is also described. A moderate but statistically significant correlation was observed between the assays, although SACT appeared to be the more sensitive of the two. Levels of antibodies correlated better with the bacterial index (BI) than with the duration of treatment. However, wide individual variations in antibody levels (for a specific duration of treatment or BI) were seen in treated as well as untreated patients. Anti-PGDS antibody response of the IgG type was poorer than that of the IgM type and, apparently, it did not have a bearing on either treatment duration or the BI. Further studies will be needed to clarify whether the treated patients showing a negative (or low) BI and high antibody levels were harboring hidden foci of active infection, and whether treatment could safely be terminated in patients showing low values for both BI and antibody^ien. Descritores: Hanseníase Virchowiana/quimioter Hanseníase Virchowiana/imunol Mycobacterium leprae/imunol Mycobacterium leprae/isol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n1/v57n1a04.pdf - en.

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Id: 27142 Autor: Job, Charles K; kahkonen, Martti E; Jacobson, Robert R; Hastings, Robert C. Título: Single lesion subpolar lepromatous leprosy and its possible mode of origin. Fonte: Int J Lep;57(1):12-19, Mar. 1989. ^bilus. Resumo: Three case reports of patients with a single, nodular, subpolar lepromatous skin lesion, one on the left elbow, another on the posterior aspect of the left leg, and the third on the extensor ulnar aspect of the right forearm, are presented. The lesions, clinically and histopathologically, resemble lepromas which develop at the site of experimental inoculation of Mycobacterium leprae in armadillos. These are sites on the body which are likely to be traumatized. With the distinct possibility of the presence of viable M. leprae in the soil of Louisiana and Texas from wild armadillos with the natural disease, it is suggested that these three patients acquired the infection from the environment and had inoculation lepromas^ien. Descritores: Hanseníase Virchowiana/etiol Hanseníase Virchowiana/imunol Hanseníase Virchowiana/microbiol Mycobacterium leprae/isol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n1/v57n1a02.pdf - en. Localização: Br191.1

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Id: 27135 Autor: Shu-Guang, Li; Vries, Rene RP. Título: HLA DQ molecules may be products of an immune suppression gene responsible for Mycobacterium leprae specific nonresponsiveness. Fonte: Int J Lepr;57(2):554-555, June 1989. ^bgraf, ^btab. Descritores: Hanseníase Virchowiana/genet Hanseníase Virchowiana/imunol Antígenos HLA-DQ/genet Antígenos HLA-DQ/imunol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n2/v57n2cor01.pdf - en. Localização: Br191.1

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Id: 27062 Autor: Gelber, Robert H. Título: Correspondence: Successful Treatment of a Lepromatous Patient With Clarithromycin. Fonte: Int. J. Lepr;63(1):113-115, 1995. ^btab. Descritores: Hanseníase Virchowiana/imunol Hanseníase Virchowiana/fisiopatol Claritromicina/imunol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1995/pdf/v63n1/v63n1cor10.pdf - en. Localização: BR191.1

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Id: 27041 Autor: Fajardo, Tranquilino T Jr; Villahermos, Laarni G; Cruz, Eduardo C. Dela; Abalos, Rodolfo M; Franzblau, Scoott G; Walsh, Gerald P. Título: Minocycline in Lepromatous Leprosy. Fonte: Int. J. Lepr;63(1):8-17, 1995. ^btab. Resumo: Twelve patients were treated with three dose levels of minocycline for 30 days, primarily to detect the dose-related effects on Mycobacterium leprae viability, followed by another 5 months of daily minocycline for overall efficacy and persistence of clinical and antibacterial effects. Subsequently, the patients were given standard WHO/MDT chemotherapy for multibacillary leprosy. Clinical improvement was recognizable during the first month, occurring much earlier among those on minocycline 200 mg daily than those who received minocycline 100 mg daily. A similar change also was observed in one patient 11 days after three daily doses of 100 mg of minocycline. At the end of 6 months, all patients were clinically improved with a slight reduction in the average bacterial index (BI) and logarithmic index of bacilli in biopsy (LIB). The effects of minocycline on viability by mouse foot pad inoculation and palmitic acid oxidation assays were noted beginning at 10 to 14 days of daily dosing and becoming more definite after 30 days of treatment. Both tests correlated fairly well. Doses of 200 mg daily did not appear to be more efficient than minocycline 100 daily. Phenolic glycolipid-I (PGL-I) antigen determinations done on some patients during the first month remained positive and did not correlate with changes in viability results. At the end of 6 months, after 5 months of 100 mg of minocycline monotherapy, no viable organisms could be demonstrated by mouse foot pad inoculation and palmitic acid oxidation assays; assays for PGL-I antigen were all negative. Descritores: Hanseníase Virchowiana/imunol Hanseníase Virchowiana/fisiopatol Minociclina/imunol Limites: Humanos Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1995/pdf/v63n1/v63n1a02.pdf - en. Localização: BR191.1

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Id: 27026 Autor: Fafutis-Morris, Mary; Guillen-Vargas, Cecilia M; Navarro-Fierro, Sergio; Morales-Ortiz, Roberto; Armendariz-Borunda, Juan. Título: Serum IL-1ra is elevated in lepromatous leprosy patients. Fonte: Int. J. Lepr;67(3):287-291, Sept., 1999. tab. Resumo: Patterns of production of specific cytokines are accepted as standards for T-lymphocyte subsets in diseases caused by intracellular parasites. These lymphocyte subsets (Th1 and Th2) have been associated with the different poles of the leprosy spectrum. Lepromatous leprosy (LL) onset correlates with cytokines produced by Th2 cells on the grounds of the patient's poor cellular immune response, i.e., interleukin 2 (IL-2) and gamma interferon (IFN-gamma) deficiency. On the other hand, tuberculoid leprosy (TL) has been associated with a Th1 response. Moreover, pro-inflammatory cytokines like IL-1 beta and tumor necrosis factor-alpha (TNF-alpha) play a major role in chronic inflammatory pathologies being IL-1ra and TNF-alpha soluble receptors, natural counterbalancing inhibitors. In light of this background, we decided to measure serum levels of IL-1 beta, IL-1ra, TNF-alpha and IL-6 in LL and TL patients, and we also studied the production in vitro of Th1 (IFN-gamma, IL-2), Th2 (IL-4, IL-10) and TNF-alpha cytokines. Our data showed that IL-1ra is highly elevated in sera from LL patients; there were no differences in Th2 cytokine levels and there were diminished levels in Th1 cytokines. (AU)^ien. Descritores: Hanseníase Virchowiana/genet Hanseníase Virchowiana/imunol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1999/pdf/v67n3/v67n3a08.pdf - en. Localização: BR191.1

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Id: 27009 Autor: Jok, Charles K; Jayakumar, J; Aschhoff, M. Título: "Large numbers" of Mycobacterium leprae are discharged from the intact skin of lepromatous patients; a preliminary report. Fonte: Int. J. Lepr;67(2):164-167, Jun., 1999. ilus, tab. Descritores: Hanseníase Virchowiana/imunol Hanseníase Virchowiana/fisiopatol Mycobacterium leprae/imunol Pele/les Pele/fisiopatol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1999/pdf/v67n2/v67n2cor02.pdf - en. Localização: BR191.1

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Id: 26911 Autor: Daniel, Ebenezer; Ebenezer, Gigi J; ffytche, Timothy J; Sigamani, Arunthathi; Job, Charles K. Título: Epithelioid granuloma in the iris of a lepromatous leprosy patient; an unusual finding. Fonte: Int. J. Lepr;68(2):152-155, Jun., 2000. ilus. Resumo: This case report depicts a case of histopathologically confirmed polar lepromatous (LL) leprosy with a bacterial index of 4+. He experienced recurrent episodes of erythema nodosum leprosum (ENL) in the first 5 years after diagnosis. Skin smears became negative after 6 years of dapsone monotherapy and have remained negative since that time. At 23 years after diagnosis, the patient had developed cataracts and underwent intracapsular cataract extractions with broad-based iridectomies. In one of the iris specimens, histopathologic examination revealed a focal granuloma composed of epithelioid cells. Subsequently a lepromin skin test showed a positive Mitsuda reaction with a borderline tuberculoid histopathology. This clearly illustrates the immunological upgrading of a polar lepromatous patient, perceived first in the iris tissue. (AU)^ien. Descritores: Hanseníase Virchowiana/imunol Hanseníase Virchowiana/fisiopatol Granuloma/compl Granuloma/fisiopatol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2000/pdf/v68n2/v68n2a05.pdf - en. Localização: BR191.1

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Id: 26909 Autor: Sharma, Pankaj; Kar, Hemant K; Kaur, Harvinder; Misra, Radhey S; Mukherjee, Ashok; Mukherjee, Rama; Rani, Rajni. Título: Induction of lepromin positivity and immunoprophylaxis in household contacts of multibacillary leprosy patients: a pilot study with a candidate vaccine, Mycobacterium w. Fonte: Int. J. Lepr;68(2):136-142, Jun., 2000. tab. Resumo: We screened 487 household contacts of multibacillary (MB) patients for evidence of disease and their lepromin status. From the 444 results available, 302 (68.02%) were lepromin positive and 142 (31.98%) were lepromin negative on initial testing. The initial lepromin status as assessed in the group of 54 contacts having disease at the outset showed 24 out of 46 (52.2%) to be lepromin positive and 22 of 46 (47.8%) to be lepromin negative. In the same group, among 24 lepromin positives, 22 (91.7%) had paucibacillary (PB) and 2 (8.3%) had multibacillary (MB) disease; among the lepromin negatives, 12 (54.5%) had PB and 10 (45.5%) had MB disease. Out of 72 initially lepromin-negative contacts administered Mycobacterium w vaccine and followed up, the cumulative percentages show that 53 (73.6%) converted to positivity after a single dose, 10 (87.5%) after a second dose and 67 (93.1%) after the third dose. The incidence of new cases with leprosy was 8 out of 231 (3.46%) among lepromin-positive contacts and 5 out of 93 (5.38%) among lepromin-negative contacts administered Mycobacterium w vaccine. Among 231 lepromin-positive contacts, the new cases occurred in those with a 1+ and 2+ lepromin response only, and no case occurred among 51 contacts with a 3+ lepromin response. The incidence among lepromin-positive contacts in this study (3.46%) was similar to the observations in two other studies: 3.2% by Dharmendra, et al. and 6.9% by Chaudhary, et al. However, the incidence among lepromin-negative contacts administered Mycobacterium w vaccine was significantly lower than that observed among lepromin-negative contacts not administered any vaccination in the other two studies (14.1% by Dharmendra, et al. and 29.0% by Chaudhary, et al.). To conclude, although a study of small sample size, the preliminary evaluation indicates that administration of Mycobacterium w vaccine seems to have the potential to reduce the incidence of leprosy among household contacts of leprosy patients. More explicit results about the vaccine will be available from the ongoing field trials in Kanpur Dehat in the near future. (AU)^ien. Descritores: Mycobacterium leprae/genet Mycobacterium leprae/imunol Hanseníase Dimorfa/imunol Hanseníase Virchowiana/imunol Hanseníase Tuberculóide/imunol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2000/pdf/v68n2/v68n2a03.pdf - en. Localização: BR191.1

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Id: 26908 Autor: Rea, Thomas H. Título: Trials of Daily, long-term minocycline and rifampin of clarithromycin and rifampin in the treatment of borderlinne lepromatous and lepromatous leprosy. Fonte: Int. J. Lepr;68(2):129-135, Jun., 2000. graf. Resumo: Daily, long-term treatment with minocycline 100 mg and rifampin 600 mg was initiated in 24 previously untreated borderline lepromatous (BL) and lepromatous (LL) patients for a total of 646 patient-months, averaging 26.9 months per patient. The same regimen was started in 12 BL and LL patients having a bacteriologic relapse for a total of 379 patient-months, averaging 32.5 months per patient, and in 12 patients judged to be at high risk for relapse for a total of 354 patient-months, averaging 29.5 months per patient. Daily, long-term treatment with clarithromycin 500 mg and rifampin 600 mg was initiated in 8 previously untreated BL and LL patients for a total of 174 patient-months, averaging 21.8 months per patient. The results in these 56 patients were compared to those obtained in 34 previously untreated BL and LL patients who were treated concurrently receiving daily, long-term dapsone 100 mg and rifampin 600 mg. No evidence of dangerous drug reactions or bone marrow, kidney or liver toxicity was seen in any of these five patient groups. Drug intolerance in 10 of the 90 patients studied necessitated discontinuing the chosen regimen, 4 from rifampin, 3 from dapsone, 2 from minocycline and 1 of undetermined attribution. The use of either minocycline or clarithromycin in conjunction with rifampin appears to pose no great risk when used long term. (AU)^ien. Descritores: Hanseníase Virchowiana/quimioter Hanseníase Virchowiana/imunol Minociclina/uso terap Rifampina/uso terap Claritromicina/uso terap Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2000/pdf/v68n2/v68n2a02.pdf - en. Localização: BR191.1

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Id: 26780 Autor: Suneetha, Sujai; Reddy, Rajgopal. Título: Histological resolution and bacterial clearance with pulse ROM therapy in borderline lepromatous leprosy. Fonte: Int. J. Lepr;69(1):53-54, Mar., 2001. ilus. Descritores: Hanseníase Virchowiana/imunol Hanseníase Virchowiana/fisiopatol Hanseníase Virchowiana/terap Pulsoterapia/métodos Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2001/pdf/v69n1/v69n1cor08.pdf - en. Localização: BR191.1

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Id: 26757 Autor: Arunthathi, S; Ebenezer, Gigi; Daniel, Ebenezer; Sugumaran, Samuel Thompson. Título: Nocardia farcinica pleuritis in a lepromatous patient with severe necrotizing reaction: an unusual presentation. Fonte: Int. J. Lep;69(2):104-107, Jun., 2001. ilus. Resumo: A young, male, lepromatous leprosy patient with a severe necrotizing erythema nodosum leprosum reaction treated with prolonged oral steroids and thalidomide developed pleuritis that was caused by a rare opportunistic pathogen, Nocardia farcinica. This organism was resistant to most antibiotics but was susceptible to amikacin and minocycline. During the course of treatment the patient developed severe gastritis which necessitated the removal of clofazimine and the inclusion of an H2 receptor antagonist. Bilateral steroid-induced cataracts needed surgical correction. This case is being presented for its rare opportunistic bacterial infection and for the multiple complications which made treatment difficult. (AU)^ien. Descritores: Hanseníase Virchowiana/compl Hanseníase Virchowiana/imunol Limites: Humanos Localização: BR191.1

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Id: 26737 Autor: Shabaana, Abdul Khader; Venkatasubramani, Rajendran; Shanker Narayan, Nallakandypanangadan; Hoessli, Daniel C; Dharmalingam, Kuppamuthu. Título: Cytokine profiles in paraffin-embedded biopsy samples of lepromatous leprosy patients: semi-quantitative measure of cytokine mRNA using RT-PCR. Fonte: Int. J. Lepr;69(3):204-214, Sept., 2001. ilus, tab. Resumo: A reproducible technique for fixation of tissue, RNA extraction and reverse transcription polymerase chain reaction (RT-PCR) analysis from paraffin-embedded leprosy biopsies, has been developed and used to study the mRNA profiles. This approach is valuable in retrospective analysis of gene expression, and the handling of infectious biopsy material is also minimized. Among the methods of RNA extraction compared, the most efficient method was found to be incubation of the tissue sections in digestion buffer followed by extraction with Trizol. The experimental conditions were optimized for first strand cDNA synthesis and PCR, and used to measure the quantity of cytokine transcripts in biopsy materials. Interleukin-10 (IL-10) mRNA was detectable in all cases examined, which correlates well with other earlier reports using frozen tissues. However, IL-5 transcripts were present in 60% of the biopsies, unlike the earlier reports which showed IL-5 mRNA in all LL cases. Transforming growth factor-beta (TGF-beta) mRNA was detected in 80% of the biopsies, and this confirmed earlier immuno-cytochemical data which showed TGF-beta protein in all cases. Tumor necrosis factor-alpha mRNA was found in about 60% of the biopsies; whereas interferon gamma mRNA was detected in 30% of the LL cases. In conclusion, the results obtained in our study confirm and extend earlier observations which examined cytokines in peripheral blood cells and dermal lesions of leprosy. The simplicity of this method would allow the examination of a large number of samples across the spectrum of leprosy.(AU)^ien. Descritores: Hanseníase Virchowiana/genet Hanseníase Virchowiana/imunol Hanseníase Virchowiana/fisiopatol Citocinas/genet RNA Mensageiro/genet Reação em Cadeia da Polimerase Via Transcriptase Reversa/métodos Limites: Humanos Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2001/pdf/v69n3/v69n3a04.pdf - en. Localização: BR191.1

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Id: 26662 Autor: Huizar-López, Rosario; Santerre, Ann; Madrid-Marina, Vicente; Peralta-Zaragoza, Oscar; Villalobos-Arámbula, Alma; Islas-Rodríguez, Alfonso. Título: AP-1 Is present in nuclear extracts of lymphocytes from lepromatous leprosy patients. Fonte: Int. J. Lepr;70(4):274-277, Dec., 2002. ilus, tab. Descritores: Hanseníase Virchowiana/imunol Hanseníase Virchowiana/fisiopatol Antígenos CD95/genet Antígenos CD95/imunol Linfócitos/imunol Linfócitos/fisiol Limites: Humanos Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2002/pdf/v70n4/v70n4cor.pdf - en. Localização: BR191.1

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